Oxidative stress induced by 2,4-phenoxyacetic acid in liver of female rats and their progeny: biochemical and histopathological studies.
Environ Toxicol
; 27(3): 137-45, 2012 Mar.
Article
en En
| MEDLINE
| ID: mdl-20607813
The 2,4-Dichlorophenoxyacetic acid (2,4-D) was used in agriculture as an herbicide in many countries including Tunisia. The aim of this study was to evaluate the effects of 2,4-D on liver function of adult rats and their progeny. Female Wistar rats were divided into two groups: the controls and the treated rats which received 600 ppm of 2,4-D in their drinking water from the 14th day of pregnancy until day 14 after delivery. In 2,4-D group, a significant decrease in body weight of pups was noted, when compared to controls. Liver antioxidant enzyme activities, superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) decreased, while malondialdehyde (MDA) levels increased in dams and pups. Moreover, plasma aminotransferases (ALT, AST), gamma glutamil transpeptidase (GGT), lactate dehydrogenase (LDH), bilirubin and albumin levels were increased significantly. The biochemical modifications were correlated with histopathological studies. We concluded that 2,4-D induced hepatotoxicity in adult and suckling rats.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Estrés Oxidativo
/
Ácido 2,4-Diclorofenoxiacético
/
Herbicidas
/
Hígado
Límite:
Animals
/
Pregnancy
País/Región como asunto:
Africa
Idioma:
En
Revista:
Environ Toxicol
Asunto de la revista:
SAUDE AMBIENTAL
/
TOXICOLOGIA
Año:
2012
Tipo del documento:
Article
País de afiliación:
Túnez
Pais de publicación:
Estados Unidos