The in-situ solid-state NMR spectroscopy investigation of alcoholic lactose suspensions.
Solid State Nucl Magn Reson
; 37(3-4): 75-81, 2010.
Article
en En
| MEDLINE
| ID: mdl-20605422
The polymorphic forms of lactose in alcoholic suspensions have been determined by (13)C CP-MAS NMR spectroscopy, employing hand-made glass inserts. Suspensions of alpha lactose monohydrate (Lalpha.H(2)O) with particle size between 2 and 200mum were prepared by 24h reflux or by storage for 28d in anhydrous ethanol without agitation. These suspensions were compared to an ethanolic sub-micron lactose suspension provided by a 3M Health Care (Loughborough). The (13)C CP-MAS NMR spectra indicated that Lalpha.H(2)O dehydrated to stable anhydrous alpha lactose polymorph (Lalpha(S)) whilst suspended in ethanol. In addition, strong ethanol (13)C resonances were observed for some samples, indicating a liquid-solid interaction between the ethanol and lactose surface. Replacement of ethanol with anhydrous methanol, n-butanol and 3-methylbutan-2-ol implied that the solvent mediated dehydration of Lalpha.H(2)O to Lalpha(S) occurs as a result of sterically controlled interactions.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Alcoholes
/
Lactosa
Idioma:
En
Revista:
Solid State Nucl Magn Reson
Asunto de la revista:
DIAGNOSTICO POR IMAGEM
/
MEDICINA NUCLEAR
Año:
2010
Tipo del documento:
Article
Pais de publicación:
Países Bajos