Identification of Galectin-1 as a novel biomarker in nasopharyngeal carcinoma by proteomic analysis.

Tang, Can-E; Tan, Tan; Li, Cui; Chen, Zhu-Chu; Ruan, Lin; Wang, Hong-Han; Su, Tao; Zhang, Peng-Fei; Xiao, Zhi-Qiang

Tang, Can-E; Tan, Tan; Li, Cui; Chen, Zhu-Chu; Ruan, Lin; Wang, Hong-Han; Su, Tao; Zhang, Peng-Fei; Xiao, Zhi-Qiang.

Afiliación

Tang CE; Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, Medicine Research Center, Xiangya Hospital, Central South University, Changsha 410008, PR China.

Oncol Rep ; 24(2): 495-500, 2010 Aug.

Article en En | MEDLINE | ID: mdl-20596638

RESUMEN

Nasopharyngeal carcinoma (NPC) is one of the most common malignant tumors in southern China and Southeast Asia. It is characterized as a multistep process involved in multiple genetic and epigenetic events. The mechanism of carcinogenesis still needs to be further clarified. In this study, two-dimensional gel electrophoresis, matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF-MS), RT-PCR, Western blot and immunohistochemical (IHC) analyses were used to detect Galectin-1 expression in NPC compared with normal nasopharyngeal epithelial tissues (NNET). We found that Galectin-1 was expressed at a significantly higher level in NPC compared with NNET. Our results indicated that high expression level of Galectin-1 might correlate with the development of NPC and Galectin-1 may serve as a potential diagnostic marker or therapeutic target for NPC.

Asunto(s)

Carcinoma/metabolismo; Galectina 1/metabolismo; Neoplasias Nasofaríngeas/metabolismo; Proteómica; Secuencia de Aminoácidos; Biomarcadores de Tumor/genética; Biomarcadores de Tumor/metabolismo; Biomarcadores de Tumor/fisiología; Carcinoma/diagnóstico; Carcinoma/genética; Electroforesis en Gel Bidimensional; Galectina 1/análisis; Galectina 1/genética; Galectina 1/fisiología; Humanos; Espectrometría de Masas; Datos de Secuencia Molecular; Neoplasias Nasofaríngeas/diagnóstico; Neoplasias Nasofaríngeas/genética; Pronóstico; Reacción en Cadena de la Polimerasa de Transcriptasa Inversa

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma / Neoplasias Nasofaríngeas / Galectina 1 / Proteómica Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Oncol Rep Asunto de la revista: NEOPLASIAS Año: 2010 Tipo del documento: Article Pais de publicación: Grecia

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