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Systemic mastocytosis and bone involvement in a cohort of 75 patients.
Barete, S; Assous, N; de Gennes, C; Grandpeix, C; Feger, F; Palmerini, F; Dubreuil, P; Arock, M; Roux, C; Launay, J M; Fraitag, S; Canioni, D; Billemont, B; Suarez, F; Lanternier, F; Lortholary, O; Hermine, O; Francès, C.
Afiliación
  • Barete S; AP-HP, Dermatology and Allergy Department, Université Pierre et Marie Curie, Tenon Hospital, 4 rue Chine, Paris 75020, France. stephane.barete@psl.aphp.fr
Ann Rheum Dis ; 69(10): 1838-41, 2010 Oct.
Article en En | MEDLINE | ID: mdl-20570833
OBJECTIVES: To investigate bone involvement in a large cohort of systemic mastocytosis (SM) patients, and evaluate the efficacy of bisphosphonate therapy. PATIENTS AND METHODS: From 2000 to 2004, 75 patients with SM according to WHO criteria underwent skeletal x-rays and bone mineral density (BMD) assessment. Sequential BMD assessments were performed in nine patients treated with bisphosphonate (mean follow-up 65 months). RESULTS: 37 patients (49%) had bone involvement according to both x-rays and BMD evaluations: osteoporosis (23 patients, 31%, mean lumbar spine T score: -3 SD), with vertebral fracture (13 patients, 17%), axial skeleton osteosclerosis (six patients, 8%), mixed patterns (three patients), osteopenia with pre-existing fractures (four patients) and focal osteolytic lesion (one patient). Blood count abnormalities were associated with osteosclerosis (p=0.005). In nine patients with osteoporosis and bisphosphonate therapy, mean lumbar spine BMD increased from 0.83 to 0.92 g/cm(2) (+11.1%; ie, +2.05% per year) without recurrence of vertebral fracture. CONCLUSION: Half of adult patients with SM have bone involvement. Osteoporosis is the most prevalent bone manifestation in SM (31%). Bisphosphonate therapy seems efficient to improve lumbar spine BMD during SM-related osteoporosis. Spine x-ray and BMD should be performed in all SM patients to detect those who may benefit from anti-osteoporotic therapy.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteoporosis / Mastocitosis Sistémica Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Rheum Dis Año: 2010 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteoporosis / Mastocitosis Sistémica Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Rheum Dis Año: 2010 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido