[Expression of IL-8, SP-A and TGF-beta1 in bronchoalveolar lavage fluid of neonates with bronchopulmonary dysplasia].
Zhongguo Dang Dai Er Ke Za Zhi
; 12(6): 444-6, 2010 Jun.
Article
en Zh
| MEDLINE
| ID: mdl-20540853
OBJECTIVE: To investigate the expression of interleukin 8 (IL-8), surfactant protein-A (SP-A) and transforming growth factor beta1 (TGF-beta1) in bronchoalveolar lavage fluid (BALF) of neonates with bronchopulmonary dysplasia (BPD). METHODS: Thirty neonates with BPD and 30 gestational age-, gender-, and birth weight-matched neonates without BPD (control group) were enrolled from December 2007 to October 2009. Non-brochoscopic bronchoalveolar lavage was performed. The levels of IL-8, SP-A and TGF-beta1 in BALF were measured using ELISA. RESULTS: The levels of TGF beta1 (47+/-15 microg/mL vs 34+/-13 microg/mL) and IL-8 (54+/-16 microg/mL vs 28+/-13 microg/mL) in the BPD group were significantly higher than those in the control group (P<0.01). In contrast, the contents of SP-A in the BPD group were significantly lower than those in the control group (35+/-16 microg/mL vs 42+/-14 microg/mL;P<0.05). CONCLUSIONS: The increased expression of TGF-beta1 and IL-8 in BALF may be involved in abnormal lung development and maturation in neonates with BPD. The low expression of SP-A in the BPD group suggests that the exogenous SP-A administration may be an option for the treatment of BPD.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Displasia Broncopulmonar
/
Líquido del Lavado Bronquioalveolar
/
Interleucina-8
/
Proteína A Asociada a Surfactante Pulmonar
/
Factor de Crecimiento Transformador beta1
Límite:
Female
/
Humans
/
Male
/
Newborn
Idioma:
Zh
Revista:
Zhongguo Dang Dai Er Ke Za Zhi
Año:
2010
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
China