A 28-day oral toxicity study of fermentation-derived cellulose, produced by Acetobacter aceti subspecies xylinum, in F344 rats.
J Toxicol Sci
; 35(3): 317-25, 2010 Jun.
Article
en En
| MEDLINE
| ID: mdl-20519840
This study was designed to evaluate any adverse effect of fermentation-derived cellulose, produced by Acetobacter aceti subspecies xylinum, when administered to both sexes of F344 rats at dietary levels of 0, 1.25, 2.5, and 5.0% for 28 days. The treatment had no adverse effects on clinical signs, mortality, body weights and food and water consumption, or on urinalysis, ophthalmology, hematology, blood biochemistry, and histopathology findings. At necropsy, slight increased absolute and relative cecum weights, evident in females ingesting 2.5% and 5.0% dietary levels, were considered to be a physiological adaptation to the poorly absorbed fermentation-derived cellulose. The non-observed-adverse-effect level (NOAEL) from the present study was concluded to be 5.0% in the diet (5,331 mg/kg body weights/day for males, and 5,230 mg/kg body weights/day for females).
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Celulosa
/
Gluconacetobacter xylinus
/
Fermentación
Límite:
Animals
Idioma:
En
Revista:
J Toxicol Sci
Año:
2010
Tipo del documento:
Article
País de afiliación:
Japón
Pais de publicación:
Japón