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Acquiring human immunodeficiency virus during pregnancy and mother-to-child transmission in New York: 2002-2006.
Birkhead, Guthrie S; Pulver, Wendy P; Warren, Barbara L; Hackel, Sheila; Rodríguez, Deborah; Smith, Lou.
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  • Birkhead GS; From New York State Department of Health, Office of Public Health and Department of Epidemiology, School of Public Health, University at Albany, Albany, New York; New York State Department of Health, Center for Community Health, Albany, New York; New York State Department of Health, Acquired Immunodeficiency Syndrome (AIDS) Institute, New York; New York State Department of Health, AIDS Institute, Albany, New York; New York State Department of Health, Wadsworth Center, Albany, New York; and New Y
Obstet Gynecol ; 115(6): 1247-1255, 2010 Jun.
Article en En | MEDLINE | ID: mdl-20502297
OBJECTIVE: To assess perinatal human immunodeficiency virus (HIV) exposure and factors associated with mother-to-child HIV transmission. METHODS: A cohort analysis of HIV-exposed births in New York State from 2002 to 2006 was undertaken using routinely collected public health surveillance and regulatory data, including Newborn Screening HIV antibody results, pediatric HIV diagnostic test results, and maternal and pediatric medical record abstractions. RESULTS: Between January 2002 and December 2006, we identified 3,396 HIV-exposed neonoates. Subsequent analysis of 3,102 (91%) birth events showed that mother-to-child HIV transmission was presumed or confirmed to have occurred in 65 neonates (2.1%) born to 63 mothers. On multivariable analysis, the following significant associations with transmission were identified: maternal HIV diagnosis at or after delivery (odds ratio [OR] 3.24, 95% [CI] 1.15-8.15), maternal acquisition of HIV during pregnancy (OR 15.19, 95% CI 3.98-56.30), illicit substance use during pregnancy (OR 2.66, 95% CI 1.33-5.27), 0-2 prenatal care visits (OR 2.37, 95% CI 1.11-4.91), and neonatal birth weight less than 2,500 g (OR 2.46, 95% CI 1.26-4.74). CONCLUSION: Acquisition of HIV during pregnancy is a significant risk factor for mother-to-child HIV transmission and must be addressed along with other known risks to reduce mother-to-child transmission to the greatest extent possible. LEVEL OF EVIDENCE: II.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complicaciones Infecciosas del Embarazo / Infecciones por VIH / Transmisión Vertical de Enfermedad Infecciosa Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Newborn / Pregnancy País/Región como asunto: America do norte Idioma: En Revista: Obstet Gynecol Año: 2010 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complicaciones Infecciosas del Embarazo / Infecciones por VIH / Transmisión Vertical de Enfermedad Infecciosa Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Newborn / Pregnancy País/Región como asunto: America do norte Idioma: En Revista: Obstet Gynecol Año: 2010 Tipo del documento: Article Pais de publicación: Estados Unidos