[Adult T-cell leukemia induced by HTLV-1: before and after HBZ]. / Leucémies T induites par HTLV-1 : y a-t-il un avant et un après HBZ ?
Med Sci (Paris)
; 26(4): 391-6, 2010 Apr.
Article
en Fr
| MEDLINE
| ID: mdl-20412744
Adult T-cell leukemia (ATL) is an often fatal leukemia of CD4+ T lymphocytes associated with a complex retrovirus, human T-cell leukemia virus type 1 (HTLV-1). Although the viral Tax protein is involved in the proliferation of infected cells during the preleukemic stages, Tax expression is not systematically detected in primary leukemic cells. In 2002, we described the characterization of a novel viral protein that we have termed HBZ for HTLV-1 bZIP factor. This viral factor is encoded on the antisense strand of HTLV-1 proviral DNA, demonstrating the existence of antisense transcription from a promoter located in the 3' LTR. HBZ can negatively control the expression of the other viral proteins by blocking the interaction between Tax and ATF/CREB factors and the recruitment of CBP/p300 by Tax on the promoter. Moreover, recent studies found that the viral HBZ gene was always expressed in leukemic cells, suggesting its involvement in the progression of the infected cells towards malignancy.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Virales
/
Virus Linfotrópico T Tipo 1 Humano
/
Leucemia-Linfoma de Células T del Adulto
/
Regulación Viral de la Expresión Génica
/
Transformación Celular Viral
/
Factores de Transcripción con Cremalleras de Leucina de Carácter Básico
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
Fr
Revista:
Med Sci (Paris)
Asunto de la revista:
MEDICINA
Año:
2010
Tipo del documento:
Article
País de afiliación:
Francia
Pais de publicación:
Francia