In utero and lactational exposure to low doses of chlorinated and brominated dioxins induces deficits in the fear memory of male mice.
Neurotoxicology
; 31(4): 385-90, 2010 Aug.
Article
en En
| MEDLINE
| ID: mdl-20398696
Environmental-level in utero and lactational exposures to dioxins have been considered to affect brain functions of offspring. Here, we determined whether in utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and 2,3,7,8-tetrabromodibenzo-p-dioxin (TBDD), at the dose that does not harm the dams, affects the acquisition and retention of fear memory in mouse offspring. Pregnant C57BL/6J mice were administered by gavages TCDD or TBDD at a dose of 0 or 3.0 microg/kg body weight on gestation day 12.5, and their male offspring were examined for their behavior in adulthood. In the fear conditioning, a paired presentation of tone and foot shock was repeated three times, and retention tests for contextual and auditory fear memory were carried out 1 and 24h after the fear conditioning. Groups of mice that were exposed to TCDD and TBDD in utero and via lactation showed deficits in the contextual and auditory retention tests at 1 and 24h retention intervals. The present results suggest that maternal exposure to a low dose of TCDD or TBDD disrupts the functions of memory and emotion in male mouse offspring, and that the developmental toxicities of these chemicals are similar to each other.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Efectos Tardíos de la Exposición Prenatal
/
Lactancia Materna
/
Dioxinas
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Contaminantes Ambientales
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Miedo
/
Dibenzodioxinas Policloradas
/
Memoria
Límite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Neurotoxicology
Año:
2010
Tipo del documento:
Article
País de afiliación:
Japón
Pais de publicación:
Países Bajos