Strain diversity within Mycobacterium avium subspecies paratuberculosis--a review.
Indian J Exp Biol
; 48(1): 7-16, 2010 Jan.
Article
en En
| MEDLINE
| ID: mdl-20358861
Mycobacterium avium subspecies paratuberculosis (MAP), is the etiological agent of Johne's disease (or paratuberculosis) in animals and has also been linked with Crohn's disease of human beings. Extreme fastidious nature of the organism (MAP) has hampered studies on diversity within the organism. Studies based on phenotypic properties like growth rate, pigmentation, lipid profile etc., are unable to provide complete information on diversity of MAP organism in nature. However, with the advent of molecular assays (IS900 RFLP, PFGE, IS1311 PCR-REA, SSR typing, VNTR typing etc.) in last 2 decades, progress has been made to differentiate MAP strains. MAP isolates have been classified into various types and subtypes using these molecular tools. Optimization of these typing assays has led to generation of new information about MAP strains, subtypes, their comparative genomics, relative evolution, comparative virulence etc. Knowledge of strain diversity is important for better understanding of molecular and sero-epidemiology, infection and patho-biology, vaccine development and planning control strategies. The present review provides available information on MAP strains, ho st adaptations, their virulence,comparative genomics, relative genetic evolution and differentiation.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Mycobacterium avium subsp. paratuberculosis
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Indian J Exp Biol
Año:
2010
Tipo del documento:
Article
País de afiliación:
India
Pais de publicación:
India