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A phase II study of bevacizumab, oxaliplatin, and docetaxel in locally advanced and metastatic gastric and gastroesophageal junction cancers.
El-Rayes, B F; Zalupski, M; Bekai-Saab, T; Heilbrun, L K; Hammad, N; Patel, B; Urba, S; Shields, A F; Vaishampayan, U; Dawson, S; Almhanna, K; Smith, D; Philip, P A.
Afiliación
  • El-Rayes BF; Department of Internal Medicine, Division of Hematology and Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI. Electronic address: belraye@emory.edu.
  • Zalupski M; Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan, Ann Arbor, MI.
  • Bekai-Saab T; Department of Internal Medicine, Division of Hematology and Oncology, The Ohio State University, Arthur-James Cancer Center, Columbus, OH.
  • Heilbrun LK; Department of Biostatisics, Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA.
  • Hammad N; Department of Internal Medicine, Division of Hematology and Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI.
  • Patel B; Department of Internal Medicine, Division of Hematology and Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI.
  • Urba S; Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan, Ann Arbor, MI.
  • Shields AF; Department of Internal Medicine, Division of Hematology and Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI.
  • Vaishampayan U; Department of Internal Medicine, Division of Hematology and Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI.
  • Dawson S; Department of Internal Medicine, Division of Hematology and Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI.
  • Almhanna K; Department of Internal Medicine, Division of Hematology and Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI.
  • Smith D; Department of Biostatisics, Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA.
  • Philip PA; Department of Internal Medicine, Division of Hematology and Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI.
Ann Oncol ; 21(10): 1999-2004, 2010 Oct.
Article en En | MEDLINE | ID: mdl-20332133
BACKGROUND: Bevacizumab has demonstrated antitumor activity in multiple diseases. This phase II study was undertaken to determine the effects of adding bevacizumab to a regimen of docetaxel and oxaliplatin in patients with advanced adenocarcinoma of the stomach or gastroesophageal junction. PATIENTS AND METHODS: Previously untreated patients with locally advanced or metastatic disease and a performance status (PS) of 0-1 were eligible for this study. Patients received bevacizumab at 7.5 mg/kg, docetaxel at 70 mg/m(2), and oxaliplatin at 75 mg/m(2) administered on day 1 of a 21-day cycle. The primary end point of the study was progression-free survival (PFS). RESULTS: A total of 38 eligible patients (median age 57 years, 45% gastric, 55% PS 0) were enrolled on to the study. Median PFS was 6.6 months [95% confidence interval (CI) 4.4-10.5] and median survival 11.1 months (95% CI 8.2-15.3). Complete responses were documented in 2 (5%) patients, partial responses in 14 (37%), and stable disease in 14 (37%). No treatment-related deaths were observed. The most commonly reported grade 3-4 toxicity was neutropenia (34%), and gastrointestinal perforation occurred in three patients (8%). CONCLUSION: The combination of bevacizumab, docetaxel, and oxaliplatin has promising activity for further evaluation in randomized trials.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Peritoneales / Neoplasias Gástricas / Neoplasias Óseas / Protocolos de Quimioterapia Combinada Antineoplásica / Unión Esofagogástrica / Neoplasias Hepáticas / Neoplasias Pulmonares Tipo de estudio: Clinical_trials Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Oncol Asunto de la revista: NEOPLASIAS Año: 2010 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Peritoneales / Neoplasias Gástricas / Neoplasias Óseas / Protocolos de Quimioterapia Combinada Antineoplásica / Unión Esofagogástrica / Neoplasias Hepáticas / Neoplasias Pulmonares Tipo de estudio: Clinical_trials Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Oncol Asunto de la revista: NEOPLASIAS Año: 2010 Tipo del documento: Article Pais de publicación: Reino Unido