Novel avermectins produced by mutational biosynthesis.

Dutton, C J; Gibson, S P; Goudie, A C; Holdom, K S; Pacey, M S; Ruddock, J C; Bu'Lock, J D; Richards, M K

Dutton, C J; Gibson, S P; Goudie, A C; Holdom, K S; Pacey, M S; Ruddock, J C; Bu'Lock, J D; Richards, M K.

Afiliación

Dutton CJ; Central Research Division, Pfizer Ltd., Kent, England.

J Antibiot (Tokyo) ; 44(3): 357-65, 1991 Mar.

Article en En | MEDLINE | ID: mdl-2026561

RESUMEN

Avermectins with a wide range of novel C-25 substituents have been prepared by feeding carboxylic acids or their biosynthetic precursors to a Streptomyces avermitilis mutant strain ATCC 53568. This organism lacks the ability to form isobutyric and S-2-methylbutyric acids from their 2-oxo acid precursors and thus is unable to produce natural avermectins unless supplied with these acids. The novel avermectins produced by mutational biosynthesis possess broad-spectrum antiparasitic activity.

Asunto(s)

Antihelmínticos/metabolismo; Ivermectina/análogos & derivados; Streptomyces/metabolismo; Animales; Antihelmínticos/química; Antihelmínticos/farmacología; Caenorhabditis/efectos de los fármacos; Ácidos Carboxílicos/metabolismo; Cromatografía Líquida de Alta Presión; Dípteros; Fermentación; Ivermectina/química; Ivermectina/metabolismo; Ivermectina/farmacología; Estructura Molecular; Mutación; Streptomyces/genética

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Streptomyces / Ivermectina / Antihelmínticos Límite: Animals Idioma: En Revista: J Antibiot (Tokyo) Año: 1991 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Reino Unido

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