Sodium-dependent inhibition of amino acid and dipeptide transport by harmaline in monkey small intestine.
Biochem Pharmacol
; 29(5): 713-6, 1980 Mar 01.
Article
en En
| MEDLINE
| ID: mdl-20227945
The effect of harmaline on amino acid and dipeptide uptake was studied in the monkey. Harmaline inhibited both the systems. Preincubation of the tissue with 4 mmole/1 harmaline for 10 min was necessary for maximal inhibition. The uptake of glycyl-l-leucine- ((14)C) and ((14)C)-glycyl-l-leucine was inhibited to the same extent. The uptake of glycyl-l-proline, a dipeptide which was presumably taken up intact by the mucosal cells, was also inhibited. Total replacement of sodium in the medium reduced the uptake of both glycyl-l-leucine and glycyl-l-proline. But the uptake of these dipeptides was not inhibited by harmaline in the absence of sodium. However, the sodium-independent uptake of glycyl-l-leucine and glycyl-l-proline was also inhibited by other dipeptides.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Dipéptidos
/
Aminoácidos
/
Harmalina
/
Intestino Delgado
Límite:
Animals
Idioma:
En
Revista:
Biochem Pharmacol
Año:
1980
Tipo del documento:
Article
País de afiliación:
India
Pais de publicación:
Reino Unido