[Immunohistochemical evaluation of topoisomerase IIalpha as proliferation factor in gastric lymphoma]. / Evaluarea imunohistochimica a topoizomerazei IIalpha ca factor de proliferare in limfoamele gastrice.
Rev Med Chir Soc Med Nat Iasi
; 112(3): 738-43, 2008.
Article
en Ro
| MEDLINE
| ID: mdl-20201262
UNLABELLED: Topoisomerase IIalpha is a nuclear enzyme essential for DNA replication, with presumed prognostic value in various tumors. MATERIAL AND METHODS: Study group included 34 gastric lymphomas. Tissue samples, formalin-fixed, paraffin-embedded, were investigated by immunhistochemistry using monoclonal antibodies anti Ki67 and anti topoisomerase IIalpha. RESULTS: The 34 gastric lymphomas were previously diagnosed as follows: 14 MALT lymphoma and 20 aggressive lymphoma (17 diffuse large B-cell lymphoma, 2 diffuse large B-cell lymphoma with minor MALT component and 1 peripheral T-cell lymphoma). Both markers (Ki67 and topoisomerase IIalpha) were positive in 2-31% of tumor cells in MALT lymphoma, while in aggressive lymphoma up to 46-98% of tumor cells showed a positive expression. CONCLUSION: Similar expression of Ki67 and topoisomerase IIalpha recommends the utilization of topoisomerase IIalpha in determining the proliferation fraction in gastric lymphomas. In addition, we suggest that it might be possible to use topoisomerase II inhibitor agents in high grade gastric lymphomas.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Gástricas
/
Biomarcadores de Tumor
/
ADN-Topoisomerasas de Tipo II
/
Proteínas de Unión al ADN
/
Linfoma
/
Antígenos de Neoplasias
Tipo de estudio:
Observational_studies
/
Prognostic_studies
Límite:
Humans
Idioma:
Ro
Revista:
Rev Med Chir Soc Med Nat Iasi
Año:
2008
Tipo del documento:
Article
Pais de publicación:
Rumanía