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Functional impairment of the arterial wall in primary Sjögren's syndrome: combined action of immunologic and inflammatory factors.
Gerli, Roberto; Vaudo, Gaetano; Bocci, Elena Bartoloni; Schillaci, Giuseppe; Alunno, Alessia; Luccioli, Filippo; Hijazi, Raed; Mannarino, Elmo; Shoenfeld, Yehuda.
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  • Gerli R; University of Perugia, Perugia, Italy. gerlir@unipg.it
Arthritis Care Res (Hoboken) ; 62(5): 712-8, 2010 May.
Article en En | MEDLINE | ID: mdl-20191479
OBJECTIVE: Primary Sjögren's syndrome (SS) shares clinical and serologic features with rheumatoid arthritis and systemic lupus erythematosus, 2 diseases characterized by acceleration of atherosclerosis. Signs of precocious atherosclerosis have also been shown in SS, although the pathogenic basis of early arterial damage is unclear. The arterial wall was functionally evaluated in SS subjects with analysis of the role played by disease-related factors. METHODS: Endothelium-dependent flow-mediated vasodilation (FMV) and endothelium-independent nitrate-mediated vasodilation (NMV) were evaluated in 45 women with SS and 59 age-matched female controls. In addition, serum soluble intercellular adhesion molecule 1, soluble vascular cell adhesion molecule 1 (VCAM-1), and nitrotyrosine were detected. RESULTS: Although patient FMV values did not differ from those of control subjects (mean +/- SD 7.4 +/- 3.6 versus 7.7 +/- 1.9; not significant), NMV was lower in SS patients than in controls (mean +/- SD 8.1 +/- 3.5 versus 10.3 +/- 2.1; P
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vasodilatación / Arteria Braquial / Endotelio Vascular / Síndrome de Sjögren / Aterosclerosis Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Middle aged Idioma: En Revista: Arthritis Care Res (Hoboken) Asunto de la revista: REUMATOLOGIA Año: 2010 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vasodilatación / Arteria Braquial / Endotelio Vascular / Síndrome de Sjögren / Aterosclerosis Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Middle aged Idioma: En Revista: Arthritis Care Res (Hoboken) Asunto de la revista: REUMATOLOGIA Año: 2010 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos