Synthesis and Preliminary Evaluation of Duocarmycin Analogues Incorporating the 1,2,11,11a-Tetrahydrocyclopropa[c]naphtho[2,3-e]indol-4-one (CNI) and 1,2,11,11a-Tetrahydrocyclopropa[c]naphtho[1,2-e]indol-4-one (iso-CNI) Alkylation Subunits.

Gauss, Carla M; Hamasaki, Akiyuki; Parrish, Jay P; Macmillan, Karen S; Rayl, Thomas J; Hwang, Inkyu; Boger, Dale L

Gauss, Carla M; Hamasaki, Akiyuki; Parrish, Jay P; Macmillan, Karen S; Rayl, Thomas J; Hwang, Inkyu; Boger, Dale L.

Afiliación

Gauss CM; Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

Tetrahedron ; 65(33): 6591-6599, 2009 Aug 15.

Article en En | MEDLINE | ID: mdl-20161204

RESUMEN

Efficient syntheses and a preliminary evaluation of 1,2,11,11a-tetrahydrocyclopropa[c]-naphtho[2,3-e]indole (CNI) and 1,2,11,11a-tetrahydrocyclopropa[c]naphtho[1,2-e]indole (iso-CNI), and their derivatives containing an anthracene and phenanthrene variant of the CC-1065 or duocarmycin alkylation subunit are detailed.

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Tetrahedron Año: 2009 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

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