Your browser doesn't support javascript.
loading
In vitro inactivation of aminoglycosides by sulbactam, other beta-lactams, and sulbactam-beta-lactam combinations.
Fuchs, P C; Stickel, S; Anderson, P H; Barry, A L; Shilling, S.
Afiliación
  • Fuchs PC; St. Vincent Hospital and Medical Center, Portland, Oregon 97225.
Antimicrob Agents Chemother ; 35(1): 182-4, 1991 Jan.
Article en En | MEDLINE | ID: mdl-2014975
At clinically achievable levels (e.g., 25 micrograms/ml), sulbactam exerted no effect on aminoglycoside concentrations when incubated together in pooled serum at 37 degrees C for up to 24 h. Sulbactam alone and in combination with ampicillin or cefoperazone inactivated tobramycin, gentamicin, netilmicin, and amikacin in vitro when the sulbactam concentration was 200 to 225 micrograms/ml. At 75 micrograms/ml, sulbactam inactivated only tobramycin. Inactivation of tobramycin by high concentrations of sulbactam occurred even at -20 degrees C, but not at -70 degrees C, and was influenced by the serum matrix.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sulbactam / Antibacterianos Idioma: En Revista: Antimicrob Agents Chemother Año: 1991 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sulbactam / Antibacterianos Idioma: En Revista: Antimicrob Agents Chemother Año: 1991 Tipo del documento: Article Pais de publicación: Estados Unidos