Influence of amygdaloid glutamatergic receptors on sensory and emotional pain-related behavior in the neuropathic rat.
Behav Brain Res
; 209(1): 174-8, 2010 May 01.
Article
en En
| MEDLINE
| ID: mdl-20097232
The role of amygdaloid glutamatergic receptors (GluRs) in maintenance of the sensory versus emotional component of neuropathic pain was studied by assessing monofilament-induced limb withdrawal response (sensory pain) and aversive place-conditioning behavior (emotional pain) following amygdaloid administration of various glutamatergic compounds in nerve-injured animals. The results indicate that endogenous activation of amygdaloid group I metabotropic GluRs, mGluR(1) and mGluR(5), and the NMDA-R contributes to maintenance of sensory and emotional components of neuropathic pain. The predominant effect by amygdaloid group I mGluRs was facilitation of emotional-like pain behavior.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Dolor
/
Receptores de Glutamato
/
Neuropatías Peroneas
/
Emociones
/
Amígdala del Cerebelo
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Revista:
Behav Brain Res
Año:
2010
Tipo del documento:
Article
País de afiliación:
Finlandia
Pais de publicación:
Países Bajos