Toxic effects of multiple anticancer drugs on skin.
Pak J Pharm Sci
; 23(1): 7-14, 2010 Jan.
Article
en En
| MEDLINE
| ID: mdl-20067860
In this study, cutaneous toxicities associated with the administration of chemotherapy in combination are discussed. Rapidly growing cells are the targets of chemotherapy, so the skin, hair follicles, and nail matrix are frequently affected by chemotherapy. Chemotherapy skin reactions are more likely toxic than allergic reactions. There are numerous chemotherapy-induced cutaneous reactions that have been described in the literature. In addition to a variety of miscellaneous reactions, 19 major cutaneous reactions were discussed in current study. This study was designed to evaluate the clinical spectrum of all cutaneous toxicities over two years in hospitalized and ambulatory patients in the Department of Pediatric oncology and to establish probable relationship between the reaction and suspected anticancer protocol with the help of WHO (World Health Organization) Common Toxicity Criteria by Grade. The data on the cutaneous toxicities were analyzed by percentile and ranking method. The minimal (0.8%) cutaneous adverse effects monitored during the study were Petechiae, photosensitivity, pruritus, urticaria, wound-infection, erythema multiforme, hand-foot skin reaction, injection site reaction, dry skin. Alopecia was the single most common (64.3%) adverse effect observed during the study, where as the pigmentary changes were the second most common (18.2%) adverse effect monitored. While these side effects are generally not life threatening, they can be a source of significant distress to patients, especially alopecia.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Piel
/
Enfermedades de la Piel
/
Protocolos de Quimioterapia Combinada Antineoplásica
/
Antineoplásicos
Tipo de estudio:
Guideline
Límite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Pak J Pharm Sci
Asunto de la revista:
FARMACIA
/
FARMACOLOGIA
/
QUIMICA
Año:
2010
Tipo del documento:
Article
País de afiliación:
Pakistán
Pais de publicación:
Pakistán