In vivo visualization of macrophage infiltration and activity in inflammation using magnetic resonance imaging.
Wiley Interdiscip Rev Nanomed Nanobiotechnol
; 1(3): 272-98, 2009.
Article
en En
| MEDLINE
| ID: mdl-20049797
Because macrophages play a key role on host defense, visualization of the migration of these cells is of high relevance for both diagnostic purposes and the evaluation of therapeutic interventions. The present article addresses the use of iron oxide and gadolinium-based particles for the noninvasive in vivo detection of macrophage infiltration into inflamed areas by magnetic resonance imaging (MRI). A general introduction on the functions and general characteristics of macrophages is followed by a discussion of some of the agents and acquisition schemes currently used to track the cells in vivo. Attention is then devoted to preclinical and clinical applications in the following disease areas: atherosclerosis and myocardial infarction, stroke, multiple sclerosis, rheumatoid arthritis, and kidney transplantation.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Imagen por Resonancia Magnética
/
Aumento de la Imagen
/
Medios de Contraste
/
Nanopartículas
/
Inflamación
/
Activación de Macrófagos
/
Macrófagos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Wiley Interdiscip Rev Nanomed Nanobiotechnol
Año:
2009
Tipo del documento:
Article
País de afiliación:
Suiza
Pais de publicación:
Estados Unidos