Antitubercular potential of some semisynthetic analogues of phytol.

Saikia, Dharmendra; Parihar, Swati; Chanda, D; Ojha, S; Kumar, J K; Chanotiya, C S; Shanker, K; Negi, Arvind S

Saikia, Dharmendra; Parihar, Swati; Chanda, D; Ojha, S; Kumar, J K; Chanotiya, C S; Shanker, K; Negi, Arvind S.

Afiliación

Saikia D; Central Institute of Medicinal and Aromatic Plants (CIMAP-CSIR), Kukrail Picnic Spot Road, PO CIMAP, Lucknow 226 015, UP, India.

Bioorg Med Chem Lett ; 20(2): 508-12, 2010 Jan 15.

Article en En | MEDLINE | ID: mdl-20004575

RESUMEN

Phytol, a diterpene alcohol was modified to several semisynthetic analogues. Some of the modifications were done logically to enhance lipophilicity of the molecule. Analogues 14, 16 and 18 exhibited antitubercular activity (MIC 15.6-50microg/mL) better than phytol (100microg/mL). The most potent analogue 18 was evaluated for in vivo toxicity in Swiss albino mice and was well tolerated by the experimental animals up to 300mg/kg body weight as a single oral acute dose.

Asunto(s)

Antituberculosos/síntesis química; Oximas/síntesis química; Fitol/análogos & derivados; Animales; Antituberculosos/química; Antituberculosos/toxicidad; Ratones; Pruebas de Sensibilidad Microbiana; Mycobacterium tuberculosis/efectos de los fármacos; Oximas/química; Oximas/toxicidad; Fitol/síntesis química; Fitol/química; Fitol/toxicidad

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oximas / Fitol / Antituberculosos Límite: Animals Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2010 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido

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