Role played by the adenylcyclase-cAMP system of the rat septal area on Na+, K+ and water renal excretion.
Pharmacol Biochem Behav
; 7(2): 93-7, 1977 Aug.
Article
en En
| MEDLINE
| ID: mdl-199910
In this study, the participation of the adenylcyclase--cAMP system of the rat septal area in the mediation of the natriuretic, kaliuretic and diuretic effects of noradrenaline (NA) was investigated. The intraseptal injection of 20 nmol of NA caused a significant increase in the urinary excretion of Na+ and K+ as well as in the urinary volume during the 2 hr period following the intracerebral injection which was blocked by 40 nmol of phentolamine, locally injected, 30 min before the catecholamine. In contrast, pretreatment with propranolol (100 nmol) potentiated the effects of NA on salt and water renal excretion. The intraseptal injection of 3.12 to 50 nmol of dibutryrl cyclic adenosine monophosphate (db cAMP) caused dose-dependent increase in natriuresis and kaliuresis, but a decrease in urinary volume. Under the same experimental conditions, caffeine administration (6.25 to 100 nmol) also induced dose-dependent increases in Na+ and K+ urinary output. These results indicate that the saluretic effect of NA may be mediated by an alpha receptor-induced activation of the adenylcyclase--cAMP system in the septal area.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Potasio
/
Sodio
/
Encéfalo
/
Agua
/
Adenilil Ciclasas
/
AMP Cíclico
Límite:
Animals
Idioma:
En
Revista:
Pharmacol Biochem Behav
Año:
1977
Tipo del documento:
Article
Pais de publicación:
Estados Unidos