Choline acetyltransferase and acetylcholinesterase activities are reduced in rat striatum and frontal cortex after pilocarpine-induced seizures.
Neurosci Lett
; 469(1): 81-3, 2010 Jan 18.
Article
en En
| MEDLINE
| ID: mdl-19932735
In the present study we investigated the alterations on choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) activities in rat striatum and frontal cortex caused by pilocarpine-induced seizures. Wistar rats were treated with 0.9% saline (i.p., control group), with the association of 0.9% saline (i.p.) plus pilocarpine (400mg/kg, i.p.), 30 min before of administration of saline (pilocarpine group). After the treatments all groups were observed for 1h. The ChAT and AChE activities were measured using spectrophotometric methods and the results compared to values obtained from saline-treated animals. In pilocarpine group was observed a significantly decreases in ChAT and AChE activities in striatum and frontal cortex of adult rats, when compared to control group. Results showed that during acute phase of seizures striatal and frontal cortex ChAT and AChE activities are diminished. Our findings suggest that seizures caused cognitive dysfunction and decreases of ChAT and AChE activities that might be related, at least in part, to the neurological problems presented by epileptic patients.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pilocarpina
/
Acetilcolinesterasa
/
Convulsiones
/
Colina O-Acetiltransferasa
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Cuerpo Estriado
/
Lóbulo Frontal
Límite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Año:
2010
Tipo del documento:
Article
País de afiliación:
Brasil
Pais de publicación:
Irlanda