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Effects of antiflammins on endotoxin-induced uveitis in rats.
Chan, C C; Ni, M; Miele, L; Cordella-Miele, E; Ferrick, M; Mukherjee, A B; Nussenblatt, R B.
Afiliación
  • Chan CC; Laboratory of Immunology, National Eye Institute, Bethesda, Md. 20892.
Arch Ophthalmol ; 109(2): 278-81, 1991 Feb.
Article en En | MEDLINE | ID: mdl-1993038
Antiflammins are phospholipase A2-inhibitory, anti-inflammatory, synthetic oligopeptides derived from the region of the highest amino-acid sequence similarity between uteroglobin and lipocortin I. Endotoxin-induced uveitis is a model for anterior uveitis of the eye, which has been suggested to be induced through phospholipase A2 activation. In a preliminary report we demonstrated that topical administration of antiflammins could inhibit endotoxin-induced uveitis in rats. In this study, the anti-inflammatory effects of antiflammins were compared with those of corticosteroids on endotoxin-induced uveitis as measured by phospholipase A2 enzyme activity, inflammatory cell counts in the aqueous humor, and histopathologic features. Antiflammins are as effective as corticosteroids in their ability to suppress endotoxin-induced uveitis.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oligopéptidos / Fragmentos de Péptidos / Uteroglobina / Uveítis Anterior Límite: Animals Idioma: En Revista: Arch Ophthalmol Año: 1991 Tipo del documento: Article Pais de publicación: Estados Unidos
Buscar en Google
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oligopéptidos / Fragmentos de Péptidos / Uteroglobina / Uveítis Anterior Límite: Animals Idioma: En Revista: Arch Ophthalmol Año: 1991 Tipo del documento: Article Pais de publicación: Estados Unidos