Spontaneous aneuploidy and clone formation in adipose tissue stem cells during different periods of culturing.

Buyanovskaya, O A; Kuleshov, N P; Nikitina, V A; Voronina, E S; Katosova, L D; Bochkov, N P

Buyanovskaya, O A; Kuleshov, N P; Nikitina, V A; Voronina, E S; Katosova, L D; Bochkov, N P.

Afiliación

Buyanovskaya OA; I. M. Sechenov Moscow Medical Academy, Russian Academy of Medical Sciences, Moscow, Russia. OAB422@gmail.com

Bull Exp Biol Med ; 148(1): 109-12, 2009 Jul.

Article en En | MEDLINE | ID: mdl-19902110

RESUMEN

Cytogenetic analysis of 13 mesenchymal stem cell cultures isolated from normal human adipose tissue was carried out at different stages of culturing. The incidence of chromosomes 6, 8, 11, and X aneuploidy and polyploidy was studied by fluorescent in situ hybridization. During the early passages, monosomal cells were more often detected than trisomal ones. A clone with chromosome 6 monosomy was detected in three cultures during late passages.

Asunto(s)

Tejido Adiposo/citología; Aneuploidia; Células Clonales; Células Madre/citología; Células Cultivadas; Cromosomas Humanos; Humanos

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Madre / Tejido Adiposo / Células Clonales / Aneuploidia Límite: Humans Idioma: En Revista: Bull Exp Biol Med Año: 2009 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Estados Unidos

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