[Chronic gastrointestinal toxicity after external-beam radiation therapy for prostate cancer]. / Chronická gastrointestinální toxicita po zevní radioterapii karcinomu prostaty.
Klin Onkol
; 22(5): 233-41, 2009.
Article
en Cs
| MEDLINE
| ID: mdl-19886362
BACKGROUNDS: Chronic gastrointestinal (GI) toxicity is an important dose-limiting factor of prostate cancer treatment. Its incidence varies with the dose of radiotherapy and the external beam treatment technique; however, there are also other factors that should be considered. Despite all the efforts to diminish the incidence, chronic toxicity still remains an adverse event which can affect the quality of life in patients after prostate cancer radiotherapy. DESIGN: The aim of this review is to provide a detailed description of chronic GI toxicity after external beam radiation therapy for prostate cancer, its causes, development, symptoms and incidence in different treatment techniques, and to compare the development of GI toxicity from the beginning of curative prostate cancer radiotherapy to now. CONCLUSION: Thanks to up-to-date radiotherapy techniques, the incidence of chronic GI toxicity is relatively low despite high doses of about 80 Gy used in prostate cancer treatment. Further reduction of radiation complications could be achieved by using image-guided radiotherapy (IGRT), which enables more precise delivery of the radiation dose to the prostate, reduction of the margin around the clinical target volume (CTV) and the sparing of organs at risk.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Próstata
/
Traumatismos por Radiación
/
Tracto Gastrointestinal
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Aspecto:
Patient_preference
Límite:
Humans
/
Male
Idioma:
Cs
Revista:
Klin Onkol
Asunto de la revista:
NEOPLASIAS
Año:
2009
Tipo del documento:
Article
Pais de publicación:
República Checa