A simple stress test for the evaluation of hypothalamic-pituitary-adrenal axis during the first 6 months of life.
J Clin Endocrinol Metab
; 72(1): 214-6, 1991 Jan.
Article
en En
| MEDLINE
| ID: mdl-1986020
In 33 normal infants, divided into 3 age groups (less than 1 month, 1-3 months, and 3-6 months) plasma cortisol was measured at 2230, 2300, and 2330 h. Baseline plasma cortisol at 2230 h. was, as expected, low in all infants, with mean +/- SEM values of 41 +/- 5, 72 +/- 14, and 97 +/- 17 nmol/L in each group, respectively. Thirty and 60 min after the painful stimulus of the venipuncture, plasma cortisol increased significantly (P less than 0.0005), reaching a maximum increase up to 458 +/- 50, 392 +/- 66, and 455 +/- 97 nmol/L in each age group, respectively. We conclude that in these infants the hypothalamic-pituitary-adrenal axis was functionally intact and responded to the painful stimulus of the venipuncture by a significant increase in plasma cortisol. This test may be used as a simple procedure for the evaluation of the integrity of the hypothalamic-pituitary-adrenal axis without the administration of pharmacological agents. Its usefulness, however, should be validated with patients having a disorder of the system.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Hipófisis
/
Estrés Fisiológico
/
Hidrocortisona
/
Glándulas Suprarrenales
/
Hipotálamo
Límite:
Humans
/
Infant
/
Newborn
Idioma:
En
Revista:
J Clin Endocrinol Metab
Año:
1991
Tipo del documento:
Article
País de afiliación:
Grecia
Pais de publicación:
Estados Unidos