Your browser doesn't support javascript.
loading
Genetic association analysis of LARS2 with type 2 diabetes.
Reiling, E; Jafar-Mohammadi, B; van 't Riet, E; Weedon, M N; van Vliet-Ostaptchouk, J V; Hansen, T; Saxena, R; van Haeften, T W; Arp, P A; Das, S; Nijpels, G; Groenewoud, M J; van Hove, E C; Uitterlinden, A G; Smit, J W A; Morris, A D; Doney, A S F; Palmer, C N A; Guiducci, C; Hattersley, A T; Frayling, T M; Pedersen, O; Slagboom, P E; Altshuler, D M; Groop, L; Romijn, J A; Maassen, J A; Hofker, M H; Dekker, J M; McCarthy, M I; 't Hart, L M.
Afiliación
  • Reiling E; Department of Molecular Cell Biology, Leiden University Medical Center (LUMC), 2300RC Leiden, the Netherlands.
Diabetologia ; 53(1): 103-10, 2010 Jan.
Article en En | MEDLINE | ID: mdl-19847392
AIMS/HYPOTHESIS: LARS2 has been previously identified as a potential type 2 diabetes susceptibility gene through the low-frequency H324Q (rs71645922) variant (minor allele frequency [MAF] 3.0%). However, this association did not achieve genome-wide levels of significance. The aim of this study was to establish the true contribution of this variant and common variants in LARS2 (MAF > 5%) to type 2 diabetes risk. METHODS: We combined genome-wide association data (n = 10,128) from the DIAGRAM consortium with independent data derived from a tagging single nucleotide polymorphism (SNP) approach in Dutch individuals (n = 999) and took forward two SNPs of interest to replication in up to 11,163 Dutch participants (rs17637703 and rs952621). In addition, because inspection of genome-wide association study data identified a cluster of low-frequency variants with evidence of type 2 diabetes association, we attempted replication of rs9825041 (a proxy for this group) and the previously identified H324Q variant in up to 35,715 participants of European descent. RESULTS: No association between the common SNPs in LARS2 and type 2 diabetes was found. Our replication studies for the two low-frequency variants, rs9825041 and H324Q, failed to confirm an association with type 2 diabetes in Dutch, Scandinavian and UK samples (OR 1.03 [95% CI 0.95-1.12], p = 0.45, n = 31,962 and OR 0.99 [0.90-1.08], p = 0.78, n = 35,715 respectively). CONCLUSIONS/INTERPRETATION: In this study, the largest study examining the role of sequence variants in LARS2 in type 2 diabetes susceptibility, we found no evidence to support previous data indicating a role in type 2 diabetes susceptibility.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo 2 / Estudio de Asociación del Genoma Completo / Aminoacil-ARNt Sintetasas Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Humans Idioma: En Revista: Diabetologia Año: 2010 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo 2 / Estudio de Asociación del Genoma Completo / Aminoacil-ARNt Sintetasas Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Humans Idioma: En Revista: Diabetologia Año: 2010 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Alemania