Your browser doesn't support javascript.
loading
Effects of rosiglitazone on cardiac function in CAPD patients: a tissue Doppler study.
Akcay, Ahmet; Acar, Gurkan; Sokmen, Abdullah; Sokmen, Gulizar; Dogan, Ekrem; Sayarlioglu, Hayriye; Citirik, Cagatay; Ucar, Mehmet Ali; Tuncer, Cemal.
Afiliación
  • Akcay A; Faculty of Medicine, Department of Cardiology, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey. dr.akcay@yahoo.com.tr
Ren Fail ; 31(6): 464-9, 2009.
Article en En | MEDLINE | ID: mdl-19839823
BACKGROUND: Insulin resistance was an independent predictor of cardiovascular mortality in uremic patients without diabetes. Rosiglitazone (ROS) improves insulin sensitivity in the liver, muscle, and adipose tissue. We prospectively investigated the effects of ROS on cardiac functions by standard (SDE) and tissue Doppler echocardiography (TDI) in continuous ambulatory peritoneal dialysis (CAPD) patients. METHODS: A total of 24 CAPD patients (13 males, 11 females; mean age 42.2 +/- 14.8 years) were included. Routine blood samples were examined. Left and right ventricular functions were assessed, and myocardial performance index (MPI) was calculated by SDE and TDI at baseline and after 12-month ROS therapy. Left and right atrial volumes were measured and indexed to body surface area. RESULTS: When compared with baseline, after 12 months of ROS treatment, it was shown that early (E) and late (A) diastolic velocities of atrioventricular valves, E/A ratio, mitral E-wave deceleration time (DT), isovolumetric relaxation time (IVRT), and MPI were similar (p > 0.05). Also, no significant changes were detected in LV dimensions, LV mass index, LVEF, LA volume index, or RA volume index measured by SDE before and after ROS therapy (p > 0.05). Left and right ventricular function parameters measured by TDI including Sm, Em, Am, Em/Am ratio, E/Em ratio, and MPI were similar. CONCLUSION: It was found that there was no negative effect of long-term ROS therapy on cardiac functions measured by SDE and TDI in CAPD patients.
Asunto(s)
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vasodilatadores / Diálisis Peritoneal Ambulatoria Continua / Disfunción Ventricular Derecha / Disfunción Ventricular Izquierda / Ecocardiografía Doppler de Pulso / Tiazolidinedionas Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Ren Fail Asunto de la revista: NEFROLOGIA Año: 2009 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Reino Unido
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vasodilatadores / Diálisis Peritoneal Ambulatoria Continua / Disfunción Ventricular Derecha / Disfunción Ventricular Izquierda / Ecocardiografía Doppler de Pulso / Tiazolidinedionas Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Ren Fail Asunto de la revista: NEFROLOGIA Año: 2009 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Reino Unido