Prediction of amino acid residues protected from hydrogen-deuterium exchange in a protein chain.

Dovidchenko, N V; Lobanov, M Yu; Garbuzynskiy, S O; Galzitskaya, O V

Dovidchenko, N V; Lobanov, M Yu; Garbuzynskiy, S O; Galzitskaya, O V.

Afiliación

Dovidchenko NV; Institute of Protein Research, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia.

Biochemistry (Mosc) ; 74(8): 888-97, 2009 Aug.

Article en En | MEDLINE | ID: mdl-19817689

RESUMEN

We have investigated the possibility to predict protection of amino acid residues from hydrogen-deuterium exchange. A database containing experimental hydrogen-deuterium exchange data for 14 proteins for which these data are known has been compiled. Different structural parameters related to flexibility of amino acid residues and their amide groups have been analyzed to answer the question whether these parameters can be used for predicting the protection of amino acid residues from hydrogen-deuterium exchange. A method for prediction of protection of amino acid residues, which uses only the amino acid sequence of a protein, has been elaborated.

Asunto(s)

Proteínas Bacterianas/química; Deuterio/química; Hidrógeno/química; Proteínas de Plantas/química; Proteínas/química; Secuencia de Aminoácidos; Animales; Cinética

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas de Plantas / Proteínas Bacterianas / Proteínas / Deuterio / Hidrógeno Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: Biochemistry (Mosc) Año: 2009 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Estados Unidos

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