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Do B cells play a role in the pathogenesis of juvenile idiopathic arthritis?
Morbach, H; Girschick, H J.
Afiliación
  • Morbach H; Pediatric Rheumatology, Immunology and Infectious Diseases, Children's Hospital, University of Würzburg, Würzburg, Germany. morbach_h@kinderklinik.uni-wuerzburg.de
Autoimmunity ; 42(4): 373-5, 2009 May.
Article en En | MEDLINE | ID: mdl-19811305
Juvenile idiopathic arthritis (JIA) is the most common cause of chronic arthritis in childhood and adolescents and encompasses a heterogeneous group of diseases. The role of B cells (BC) in autoimmune diseases has been put in a new perspective due to the promising results of BC depleting therapies in RA. Experiments in mouse models have shed new light on the Ab-independent role of BC in the pathogenesis of autoimmune diseases. We discuss whether BC play a role in the pathogenesis of JIA appraising the question for an immunological basis of BC directed therapy.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Artritis Juvenil / Linfocitos B Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Adolescent / Animals / Child / Humans Idioma: En Revista: Autoimmunity Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2009 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Artritis Juvenil / Linfocitos B Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Adolescent / Animals / Child / Humans Idioma: En Revista: Autoimmunity Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2009 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido