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Recurrence of ventricular arrhythmias in patients with non-ischaemic dilated cardiomyopathy: evidence-based predictors.
Kardiol Pol ; 67(8): 837-44, 2009 Aug.
Article en En | MEDLINE | ID: mdl-19784881
BACKGROUND: Ventricular arrhythmia (VA) is the most frequent cause of sudden death among patients with non-ischaemic dilated cardiomyopathy (DCM). AIM: To identify the important VA risk factors in patients with DCM. METHODS AND RESULTS: Eighty-five DCM patients (73 males, mean age 54 years) with DCM and implantable cardioverter defibrillators (ICD) were followed for 21+/-19 months after ICD implantation. The mean follow-up was 21 months. Data from 55 patients with VA recorded in the ICD memory and requiring ICD intervention during follow-up were compared with 30 patients without arrhythmia. Cox regression analysis identified the following univariate predictors of VA: alcoholic aetiology of DCM (0.05), diuretic treatment (0.003), history of cardiac arrest (0.03), right ventricular diastolic diameter (0.001). Both ACE inhibitor (ACEI) and statin treatments were associated with a tendency towards decreased risk of VA. Multivariate logistic analysis identified four predictors as significantly related to VA: alcoholic aetiology (HR 4.8, p=0.008), ACEI treatment (HR 0.4, p=0.01), diuretic treatment (HR 2.6, p=0.015), and statin treatment (HR 0.1, p=0.03). CONCLUSIONS: The majority of patients with DCM and ICD have recurrences of VA. Alcoholic aetiology of DCM is associated with an increase in the incidence of arrhythmias. Treatment with ACEI and statins is associated with a reduction of arrhythmias.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fibrilación Ventricular / Cardiomiopatía Dilatada / Muerte Súbita Cardíaca / Desfibriladores Implantables Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Kardiol Pol Año: 2009 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Polonia
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fibrilación Ventricular / Cardiomiopatía Dilatada / Muerte Súbita Cardíaca / Desfibriladores Implantables Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Kardiol Pol Año: 2009 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Polonia