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GA(2)LEN skin test study II: clinical relevance of inhalant allergen sensitizations in Europe.
Burbach, G J; Heinzerling, L M; Edenharter, G; Bachert, C; Bindslev-Jensen, C; Bonini, S; Bousquet, J; Bousquet-Rouanet, L; Bousquet, P J; Bresciani, M; Bruno, A; Canonica, G W; Darsow, U; Demoly, P; Durham, S; Fokkens, W J; Giavi, S; Gjomarkaj, M; Gramiccioni, C; Haahtela, T; Kowalski, M L; Magyar, P; Muraközi, G; Orosz, M; Papadopoulos, N G; Röhnelt, C; Stingl, G; Todo-Bom, A; Von Mutius, E; Wiesner, A; Wöhrl, S; Zuberbier, T.
Afiliación
  • Burbach GJ; Department of Dermatology and Allergy, Charité Universitätsmedizin-Berlin, Berlin, Germany.
  • Heinzerling LM; Department of Dermatology and Allergy, Charité Universitätsmedizin-Berlin, Berlin, Germany.
  • Edenharter G; Department of Dermatology and Allergy, Charité Universitätsmedizin-Berlin, Berlin, Germany.
  • Bachert C; Department of Otorhinolaryngology, University Hospital, Ghent, Belgium.
  • Bindslev-Jensen C; University Hospital, Allergy Centre, Odense, Denmark.
  • Bonini S; Consiglio Nazionale delle Ricerche, Rome, Italy.
  • Bousquet J; University Hospital, Montpellier, France.
  • Bousquet-Rouanet L; University Hospital, Montpellier, France.
  • Bousquet PJ; University Hospital, Montpellier, France.
  • Bresciani M; Consiglio Nazionale delle Ricerche, Rome, Italy.
  • Bruno A; Consiglio Nazionale delle Ricerche, Palermo, Italy.
  • Canonica GW; Allergy Centre, University of Genoa, Genoa, Italy.
  • Darsow U; Department of Dermatology and Allergy Biederstein and Division of Environmental Dermatology and Allergy Helmholtz Center, Technical University, Technische Universität, Munich, Germany.
  • Demoly P; University Hospital, Montpellier, France.
  • Durham S; Department of Respiratory Medicine, Royal Brompton Hospital, London, UK.
  • Fokkens WJ; Department of Otorhinolaryngology, Academic Medical Centre, Amsterdam, The Netherlands.
  • Giavi S; Allergy Department, 2nd Pediatric Clinic, National and Kapodistrian University, Athens, Greece.
  • Gjomarkaj M; Consiglio Nazionale delle Ricerche, Palermo, Italy.
  • Gramiccioni C; Consiglio Nazionale delle Ricerche, Rome, Italy.
  • Haahtela T; University Central Hospital, Skin and Allergy Hospital, Helsinki, Finland.
  • Kowalski ML; Department of Clinical Immunology and Allergy, Medical University of Lodz, Lodz, Poland.
  • Magyar P; Allergy Centre, Semmelweis Medical University, Budapest, Hungary.
  • Muraközi G; Allergy Centre, Semmelweis Medical University, Budapest, Hungary.
  • Orosz M; Allergy Centre, Semmelweis Medical University, Budapest, Hungary.
  • Papadopoulos NG; Allergy Department, 2nd Pediatric Clinic, National and Kapodistrian University, Athens, Greece.
  • Röhnelt C; Department of Dermatology and Allergy, Charité Universitätsmedizin-Berlin, Berlin, Germany.
  • Stingl G; Department of Dermatology, Medical University of Vienna, Vienna, Austria.
  • Todo-Bom A; Allergy Centre, Department of Pulmonology, Coimbra University, Coimbra, Portugal.
  • Von Mutius E; Allergy Centre, Ludwig Maximilians University, Munich, Germany.
  • Wiesner A; Allergy Centre, Children's University Hospital, Zurich, Switzerland.
  • Wöhrl S; Department of Dermatology, Medical University of Vienna, Vienna, Austria.
  • Zuberbier T; Department of Dermatology and Allergy, Charité Universitätsmedizin-Berlin, Berlin, Germany.
Allergy ; 64(10): 1507-1515, 2009 Oct.
Article en En | MEDLINE | ID: mdl-19772516
BACKGROUND: Skin prick testing is the standard for diagnosing IgE-mediated allergies. A positive skin prick reaction, however, does not always correlate with clinical symptoms. A large database from a Global Asthma and Allergy European Network (GA(2)LEN) study with data on clinical relevance was used to determine the clinical relevance of sensitizations against the 18 most frequent inhalant allergens in Europe. The study population consisted of patients referred to one of the 17 allergy centres in 14 European countries (n = 3034, median age = 33 years). The aim of the study was to assess the clinical relevance of positive skin prick test reactions against inhalant allergens considering the predominating type of symptoms in a pan-European population of patients presenting with suspected allergic disease. METHODS: Clinical relevance of skin prick tests was recorded with regard to patient history and optional additional tests. A putative correlation between sensitization and allergic disease was assessed using logistic regression analysis. RESULTS: While an overall rate of >or=60% clinically relevant sensitizations was observed in all countries, a differential distribution of clinically relevant sensitizations was demonstrated depending on type of allergen and country where the prick test was performed. Furthermore, a significant correlation between the presence of allergic disease and the number of sensitizations was demonstrated. CONCLUSION: This study strongly emphasizes the importance of evaluating the clinical relevance of positive skin prick tests and calls for further studies, which may, ultimately, help increase the positive predictive value of allergy testing.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pruebas Cutáneas / Alérgenos / Exposición por Inhalación / Hipersensibilidad Inmediata Tipo de estudio: Diagnostic_studies / Evaluation_studies / Prognostic_studies Límite: Adult / Animals / Humans País/Región como asunto: Europa Idioma: En Revista: Allergy Año: 2009 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Dinamarca
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pruebas Cutáneas / Alérgenos / Exposición por Inhalación / Hipersensibilidad Inmediata Tipo de estudio: Diagnostic_studies / Evaluation_studies / Prognostic_studies Límite: Adult / Animals / Humans País/Región como asunto: Europa Idioma: En Revista: Allergy Año: 2009 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Dinamarca