Cloning and characterization of Dorsal homologues in the hemipteran Rhodnius prolixus.
Insect Mol Biol
; 18(5): 681-9, 2009 Oct.
Article
en En
| MEDLINE
| ID: mdl-19754745
Rhodnius prolixus is an ancient haematophagous hemipteran insect capable of mounting a powerful immune response. This response is transcriptionally regulated in part by transcription factors of the Rel/Nuclear Factor kappa B (Rel/NF-kappaB) family. We have cloned and characterized three members of this transcription factor family in this insect. Dorsal 1A is primarily expressed in early developmental stages. In contrast, dorsal 1B and 1C, both differentially spliced products of dorsal 1A, are expressed primarily in the adult fat body in response to septic injury, suggesting their exclusive role in immunity. Additionally, we identified putative kappaB binding sites in the 5' upstream regions of target genes known to be involved in the innate immune response of insects.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fosfoproteínas
/
Rhodnius
/
Factores de Transcripción
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Proteínas Nucleares
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Homología de Secuencia de Aminoácido
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Proteínas de Insectos
/
Proteínas de Drosophila
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Insect Mol Biol
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2009
Tipo del documento:
Article
País de afiliación:
Canadá
Pais de publicación:
Reino Unido