[Differential expression of guanylin in colorectal cancer].
Zhonghua Wei Chang Wai Ke Za Zhi
; 12(5): 515-7, 2009 Sep.
Article
en Zh
| MEDLINE
| ID: mdl-19742348
OBJECTIVE: To investigate the expression of guanylin in colorectal cancer. METHODS: The expression of guanylin was examined by RT-PCR and semiquantitative analysis in 20 cases of colorectal cancer, and its relationship with clinical characteristics was analyzed. RESULTS: The positive expression of guanylin in normal tissue (80%, 16/20) was significantly higher than that in tumor tissue (35%, 7/20) (P<0.01). The same result was found in the semiquantitative analysis of 14 cases with differential expression. Differential expression of guanylin in colorectal cancer was associate with TNM stage (P<0.05), not with sex, Borrmann type and degree of differentiation (all P>0.05). CONCLUSION: There is differential expression of guanylin in colorectal cancer, and this kind of differential expression is associated with tumor TNM stage.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Colorrectales
/
Péptidos Natriuréticos
/
Hormonas Gastrointestinales
Límite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Zh
Revista:
Zhonghua Wei Chang Wai Ke Za Zhi
Asunto de la revista:
GASTROENTEROLOGIA
Año:
2009
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
China