A short guide to hereditary diffuse gastric cancer.
Hered Cancer Clin Pract
; 5(4): 183-94, 2007 Dec 15.
Article
en En
| MEDLINE
| ID: mdl-19725995
Hereditary diffuse gastric cancer (HDGC) is the only known predisposition syndrome dominated by carcinoma of the stomach and with a recognised genetic cause. Germline mutations in the E-cadherin gene (CDH1) co-segregate with the disease in about half of the families with multiple diffuse gastric cancer. In these families, identification of the CDH1 mutation allows for clinical measures to be taken. Importantly, clinical intervention is likely to be therapeutic and associated with tolerable morbidity. This review is thus aimed at providing a current overview of the clinical management and the underlying biology of HDGC.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Hered Cancer Clin Pract
Año:
2007
Tipo del documento:
Article
Pais de publicación:
Polonia