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Prevalence of beta-2 adrenergic receptor (beta 2 AR) polymorphisms and its influence on a model used to assess endothelial function using pulse wave analysis (PWA).
Ibrahim, Nik Nor Izah Nik; Rasool, Aida Hanum Ghulam; Wong, Abdul Rahim; Rahman, Abdul Rashid Abdul.
Afiliación
  • Ibrahim NN; Department of Pharmacology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia. izah@kck.usm.my
Clin Chim Acta ; 409(1-2): 62-6, 2009 Nov.
Article en En | MEDLINE | ID: mdl-19723516
BACKGROUND: Pulse wave analysis (PWA) combined with beta(2)-agonist challenge has recently been used to assess endothelial function. beta-2 adrenergic receptor (beta(2)AR) polymorphisms may affect response to beta(2)-agonist. We determined whether beta(2)AR polymorphisms influence endothelial response in our model using PWA and salbutamol. METHODS: 388 healthy Malay subjects (177 males, 211 females) were genotyped for 5 functionally important single nucleotide polymorphisms (SNPs) of beta(2)AR; 298 subjects proceeded with assessment of endothelial function. The parameter augmentation index (AIx) was recorded non-invasively using SphygmoCor. Recording of AIx at baseline was followed by administration of 500 microg sublingual glyceryl trinitrate (GTN). AIx recordings were repeated at 3, 5, 10, 15 and 20 min post-GTN. Subjects then inhaled 400 microg of salbutamol before AIx recordings at 5 min intervals up to 20 min. Maximum changes in AIx after GTN and salbutamol represented endothelium independent and endothelium dependent vasodilatation (EDV) respectively. RESULTS: Allele frequencies of mutated Gly16, Glu27, Ile164, -20C and -47C were 47%, 6.8%, 0%, 30% and 9.3% respectively. No significant differences in EDV were noted between genotype groups of each studied SNPs. CONCLUSIONS: Assessment of endothelial function using PWA and salbutamol was not influenced by beta(2)AR polymorphisms.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores Adrenérgicos beta 2 / Polimorfismo de Nucleótido Simple / Endotelio Tipo de estudio: Prevalence_studies / Risk_factors_studies Límite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: Clin Chim Acta Año: 2009 Tipo del documento: Article País de afiliación: Malasia Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores Adrenérgicos beta 2 / Polimorfismo de Nucleótido Simple / Endotelio Tipo de estudio: Prevalence_studies / Risk_factors_studies Límite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: Clin Chim Acta Año: 2009 Tipo del documento: Article País de afiliación: Malasia Pais de publicación: Países Bajos