Surfactant replacement therapy in the neonate: beyond respiratory distress syndrome.

Donn, Steven M; Dalton, Jennifer

Donn, Steven M; Dalton, Jennifer.

Afiliación

Donn SM; Division of Neonatal-Perinatal Medicine, Department of Pediatrics, F5790, Mott Children's Hospital, University of Michigan Health System, 1500 E Medical Center Drive, Ann Arbor MI 48109-0254, USA. smdonnmd@med.umich.edu

Respir Care ; 54(9): 1203-8, 2009 Sep.

Article en En | MEDLINE | ID: mdl-19712497

RESUMEN

Surfactant-replacement therapy is a life-saving treatment for preterm infants with respiratory distress syndrome, a disorder characterized by surfactant deficiency. Repletion with exogenous surfactant decreases mortality and thoracic air leaks and is a standard practice in the developed world. In addition to respiratory distress syndrome, other neonatal respiratory disorders are characterized by surfactant deficiency, which may result from decreased synthesis or inactivation. Two of these disorders, meconium aspiration syndrome and bronchopulmonary dysplasia, might also be amenable to surfactant-replacement therapy. This paper discusses the use of surfactant-replacement therapy beyond respiratory distress syndrome and examines the evidence to date.

Asunto(s)

Displasia Broncopulmonar/tratamiento farmacológico; Síndrome de Aspiración de Meconio/tratamiento farmacológico; Surfactantes Pulmonares/uso terapéutico; Lavado Broncoalveolar/métodos; Humanos; Recién Nacido; Recien Nacido Prematuro

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Surfactantes Pulmonares / Displasia Broncopulmonar / Síndrome de Aspiración de Meconio Límite: Humans / Newborn Idioma: En Revista: Respir Care Año: 2009 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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