Synthesis and antitubercular activity of novel Schiff bases derived from d-mannitol.
Carbohydr Res
; 344(15): 2042-7, 2009 Oct 12.
Article
en En
| MEDLINE
| ID: mdl-19709650
Six Schiff base derivatives of d-mannitol, 1,6-dideoxy-1,6-bis-{[(E)-arylmethylidene]amino}-d-mannitol (6: aryl=XC(6)H(4): X=o-, m- and p- Cl or NO(2)), have been synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H(37)Rv using the Alamar Blue susceptibility test and the activity expressed as the minimum inhibitory concentration (MIC) in microg/mL. All three nitro derivatives exhibit significant activities: activities of (6d: X=o-NO(2)), (6e: X=m-NO(2)) and (6f: X=p-NO(2)) are 12.5, 25.0 and 25.0microg/mL, respectively. When compared with first line drugs, such as ethambutol, they can be considered as a good starting point to develop new lead compounds for the treatment of multidrug-resistant tuberculosis. Characterization of the new compounds 6 is generally achieved spectroscopically. The structure of compound 3 has been confirmed by X-ray crystallography.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Bases de Schiff
/
Manitol
/
Mycobacterium tuberculosis
/
Antituberculosos
Límite:
Animals
Idioma:
En
Revista:
Carbohydr Res
Año:
2009
Tipo del documento:
Article
País de afiliación:
Brasil
Pais de publicación:
Países Bajos