Field trial of oral cholera vaccines in Bangladesh: results from three-year follow-up.
Lancet
; 335(8684): 270-3, 1990 Feb 03.
Article
en En
| MEDLINE
| ID: mdl-1967730
The protective efficacy (PE) of B subunit killed whole-cell (BS-WC) and killed whole-cell-only (WC) oral cholera vaccines was assessed in a randomised double-blind field trial among children aged 2-15 years and women over 15 years in rural Bangladesh. Among the 62 285 subjects who received three doses of BS-WC, WC, or Escherichia coli K12 strain placebo, cumulative PE at 3 years of follow-up was 50% for BS-WC and 52% for WC. PE was similar against severe and non-severe cholera, but was significantly lower in children who were vaccinated at 2-5 years (26% for BS-WC; 23% for WC) than in older persons (63% for BS-WC; 68% for WC). Among persons vaccinated at 2-5 years, protection at 4-6 months of follow-up was similar to that for older persons, but rapidly waned thereafter and was not evident during the third year of follow-up. In contrast, persons vaccinated at older ages were protected even in the third year of follow-up (PE 40% for BS-WC; 62% for WC). PE was substantially higher against classical cholera (58% for BS-WC; 60% for WC) than against El Tor cholera (39% and 40%).
Palabras clave
Asia; Bacterial And Fungal Diseases--prevention and control; Bangladesh; Data Analysis; Delivery Of Health Care; Developing Countries; Diarrhea; Diarrhea, Infantile--prevention and control; Diseases; Evaluation; Examinations And Diagnoses; Health; Health Services; Immunization; Infections; Laboratory Examinations And Diagnoses; Primary Health Care; Research Methodology; Southern Asia; Vaccination
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Vacunas contra el Cólera
/
Vacunas de Productos Inactivados
/
Cólera
Tipo de estudio:
Clinical_trials
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Child
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Child, preschool
/
Female
/
Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
Lancet
Año:
1990
Tipo del documento:
Article
País de afiliación:
Bangladesh
Pais de publicación:
Reino Unido