Bilirubin and morphine glucuronidation is not inhibited by a cyclic-AMP mediated mechanism in murine liver.

Bánhegyi, G; Garzó, T; Mészáros, G; Antoni, F; Mandl, J

Bánhegyi, G; Garzó, T; Mészáros, G; Antoni, F; Mandl, J.

Afiliación

Bánhegyi G; 1st Institute of Biochemistry, Semmelweis University, Medical School, Budapest, Hungary.

Acta Biochim Biophys Hung ; 25(1-2): 87-92, 1990.

Article en En | MEDLINE | ID: mdl-1966648

RESUMEN

Several reactions of the Ist and IInd phase of biotransformation have been reported to be under a negative cyclic-AMP dependent control. Conjugation of bilirubin and glucuronidation of morphine were investigated in isolated mouse hepatocytes and in mouse hepatocyte microsomes, respectively. N6,O2-dibutyryl cyclic-AMP did not inhibit conjugation of bilirubin in isolated hepatocytes. ATP and the dissociated catalytic subunit of the cyclic-AMP dependent protein kinase did not influence the glucuronidation of morphine, while inhibited the formation of p-nitrophenol glucuronide in microsomes prepared from isolated mouse hepatocytes.

Asunto(s)

Bilirrubina/análogos & derivados; AMP Cíclico/farmacología; Hígado/metabolismo; Morfina/metabolismo; Animales; Bilirrubina/metabolismo; Biotransformación/efectos de los fármacos; Bucladesina/farmacología; AMP Cíclico/metabolismo; Glucuronatos/metabolismo; Ratones; Ratones Endogámicos; Microsomas Hepáticos/metabolismo; Fenolftaleína; Fenolftaleínas/metabolismo; Proteínas Quinasas/metabolismo

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bilirrubina / AMP Cíclico / Hígado / Morfina Límite: Animals Idioma: En Revista: Acta Biochim Biophys Hung Asunto de la revista: BIOFISICA / BIOQUIMICA Año: 1990 Tipo del documento: Article País de afiliación: Hungria Pais de publicación: Hungria

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