Influence of dexamethasone on the expression levels of P-selectin protein in multiple organs of rats with severe acute pancreatitis.
Inflamm Res
; 59(1): 31-9, 2010 Jan.
Article
en En
| MEDLINE
| ID: mdl-19655231
OBJECTIVE: To investigate the effect of dexamethasone on the expression levels of P-selectin protein in multiple organs of rats with severe acute pancreatitis (SAP). METHODS: Rats were randomly divided into sham-operated, model control, and dexamethasone-treated groups. At 3, 6, and 12 h after operation, the expression levels of P-selectin protein in one-third of the rats in each group were observed. RESULTS: In the treated group, the expression levels of P-selectin protein in the pancreas head (at 6 h), lung (at 12 h), liver (at 3 h), and spleen (at 6 and 12 h) were significantly lower than those in the model control group (P < 0.05). Additionally, the products of the staining intensity and positive rate of P-selectin protein in liver (at 3 h), lung (at 6 and 12 h), and spleen (at 12 h) in the treated group were significantly lower than those in the model control group (P < 0.05). CONCLUSIONS: Dexamethasone can inhibit P-selectin protein expression in multiple organs of SAP rats.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pancreatitis
/
Dexametasona
/
Selectina-P
/
Antiinflamatorios
Límite:
Animals
Idioma:
En
Revista:
Inflamm Res
Asunto de la revista:
ALERGIA E IMUNOLOGIA
/
PATOLOGIA
Año:
2010
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
Suiza