Protegrin antimicrobial peptides.
Curr Opin Drug Discov Devel
; 3(5): 655, 2000 Sep.
Article
en En
| MEDLINE
| ID: mdl-19649894
Protegrins are 16 to 18 amino acid, cationic antimicrobial peptides that are produced by porcine neutrophils, and are activated extracellularly by cleavage of the pro-protegrin molecule by neutrophil elastase. Biologically, the protegrins are characterized by broad-spectrum antimicrobial activity, rapid microbicidal action and low inherent ability to induce microbial resistance.Structurally, the protegrins form amphiphilic beta-sheets maintained by two intramolecular disulfides that are key for optimal biological activity. A synthetic protegrin analog, IB-367, is in clinical development as a locally administered agent in one program to prevent oral mucositis, a significant side effect of high dose chemotherapy and radiotherapy, and in another program to prevent nosocomial pneumonia in patients undergoing mechanically assisted ventilation.
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Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Curr Opin Drug Discov Devel
Asunto de la revista:
FARMACOLOGIA
/
TERAPIA POR MEDICAMENTOS
Año:
2000
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Reino Unido