Characterization of a Dispiroketal Spirolide Subclass from Alexandrium ostenfeldii.
J Nat Prod
; 72(7): 1237-40, 2009 Jul.
Article
en En
| MEDLINE
| ID: mdl-19572609
A new subclass of spirolide marine toxins, represented by spirolides H (1) and I (2), were isolated from the marine dinoflagellate Alexandrium ostenfeldii. Spirolides H and I are structurally distinct from other spirolides in that they contain a 5:6 dispiroketal ring system rather than the trispiroketal ring system characteristic of previously isolated spirolides. The structures were assigned using a combination of spectrometric and spectroscopic techniques. Previously isolated spirolides containing a cyclic imine moiety showed toxicity in the mouse bioassay. Spirolide H contains this cyclic imine moiety but does not show toxicity in the mouse assay, suggesting that the presence of the cyclic imine moiety is not the only structural requirement for toxicity.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Compuestos de Espiro
/
Dinoflagelados
/
Toxinas Marinas
Límite:
Animals
Idioma:
En
Revista:
J Nat Prod
Año:
2009
Tipo del documento:
Article
Pais de publicación:
Estados Unidos