Relapsing cutaneous leishmaniasis in a patient with ankylosing spondylitis treated with infliximab.
Am J Trop Med Hyg
; 81(1): 52-4, 2009 Jul.
Article
en En
| MEDLINE
| ID: mdl-19556566
A 31-year-old man with ankylosing spondylitis, receiving treatment with infliximab, presented with a large progressive cutaneous ulcer at the right knee. Biopsies showed Leishmania amastigotes, and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis showed Leishmania infantum as the causative agent. After treatment with miltefosine, the ulcer resolved completely, and infliximab was reinstituted because of progression of spondylitis. After 1 year, there was a recurrent ulcer at the same site being positive for Leishmania DNA by PCR. Local treatment with sodium stibogluconate resulted in complete regression. Cutaneous leishmaniasis should be added to the list of opportunistic infections associated with anti-tumor necrosis factor (TNF) treatment. Despite recurrences, antileish-manial treatment may be effective in cases without alternatives to anti-TNF therapy.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Espondilitis Anquilosante
/
Factor de Necrosis Tumoral alfa
/
Leishmaniasis Cutánea
/
Anticuerpos Monoclonales
Límite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Am J Trop Med Hyg
Año:
2009
Tipo del documento:
Article
País de afiliación:
Alemania
Pais de publicación:
Estados Unidos