Mechanisms of insulin resistance assessed by dynamic in-vivo positron emission tomography imaging.
Curr Opin Clin Nutr Metab Care
; 12(5): 508-12, 2009 Sep.
Article
en En
| MEDLINE
| ID: mdl-19550312
PURPOSE OF REVIEW: Skeletal muscle insulin resistance is a hallmark characteristic of type 2 diabetes, although the exact causes of insulin resistance are unknown. In-vivo methods to assess mechanisms that determine insulin resistance in humans are critical to improve our understanding of insulin resistance in obesity and type 2 diabetes. In this review, we examine recent studies utilizing dynamic in-vivo PET imaging in assessing insulin resistance in humans. RECENT FINDINGS: PET imaging of glucose metabolism in vivo has revealed novel and important information about the regulation of glucose metabolism in skeletal muscle. Using dynamic PET imaging, studies have impairments in glucose metabolism at multiple sites, including delivery, phosphorylation, and transport within skeletal muscle. Impairments in glucose phosphorylation as well as glucose transport defects may play an important role in understanding the disorder of skeletal muscle insulin resistance. SUMMARY: PET imaging has great potential to yield significant and promising insight into insulin resistance in skeletal muscle. Dynamic in-vivo PET imaging can provide valuable information regarding the mechanisms and specific loci of skeletal muscle insulin resistance in humans.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Resistencia a la Insulina
/
Músculo Esquelético
/
Tomografía de Emisión de Positrones
/
Glucosa
Límite:
Humans
Idioma:
En
Revista:
Curr Opin Clin Nutr Metab Care
Asunto de la revista:
CIENCIAS DA NUTRICAO
/
METABOLISMO
Año:
2009
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Reino Unido