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Prescription of antipsychotic medication to patients at ultra high risk of developing psychosis.
Nieman, Dorien H; Rike, Wera H; Becker, Hiske E; Dingemans, Peter M; van Amelsvoort, Thérèse A; de Haan, Lieuwe; van der Gaag, Mark; Denys, Damiaan A J P; Linszen, Don H.
Afiliación
  • Nieman DH; Academic Medical Center, Department of Psychiatry, University of Amsterdam, Amsterdam, The Netherlands. d.h.nieman@amc.uva.nl
Int Clin Psychopharmacol ; 24(4): 223-8, 2009 Jul.
Article en En | MEDLINE | ID: mdl-19521246
Little is known about medication prescription in a naturalistic setting to patients at ultra high risk (UHR) of developing psychosis. Antipsychotic medication prescription to UHR patients is not recommended in clinical practice guidelines based on the current evidence. The aim of this study is to investigate medication prescription to UHR patients in the Netherlands. The frequency of antipsychotic medication prescription to UHR patients (n=72) was compared with the frequency of antipsychotic medication prescription to patients who were diagnosed with a Diagnostic and Statistical Manual of Mental Disorders, fourth edition psychotic disorder at first diagnostic evaluation (n=90). Within the UHR group, frequency of antipsychotic medication prescription at baseline was compared between UHR patients who did make the transition to psychosis (n=18) and UHR patients who did not (n=54). No significant differences were found in antipsychotic medication prescription to UHR patients and to patients who turned out to have a florid psychosis: 51% in the psychotic group and 58% in the UHR group used no medication. Thirty-four percent in the psychotic group and 21% in the UHR group used antipsychotic medication. There was also no difference in medication prescription between UHR patients who did and did not make the transition to psychosis. More research should be aimed at developing and implementing clinical practice guidelines for the treatment of UHR patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos Psicóticos / Antipsicóticos / Prescripciones Tipo de estudio: Etiology_studies / Guideline / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Child / Female / Humans / Male Idioma: En Revista: Int Clin Psychopharmacol Asunto de la revista: PSICOFARMACOLOGIA Año: 2009 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos Psicóticos / Antipsicóticos / Prescripciones Tipo de estudio: Etiology_studies / Guideline / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Child / Female / Humans / Male Idioma: En Revista: Int Clin Psychopharmacol Asunto de la revista: PSICOFARMACOLOGIA Año: 2009 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido