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Favorable impact of the interleukin-4 receptor allelic variant I75 on the survival of diffuse large B-cell lymphoma patients demonstrated in a large prospective clinical trial.
Schoof, N; von Bonin, F; Zeynalova, S; Ziepert, M; Jung, W; Loeffler, M; Pfreundschuh, M; Trümper, L; Kube, D.
Afiliación
  • Schoof N; Department of Hematology and Oncology, Medical Center of the Georg-August-University of Göttingen, Göttingen. Electronic address: nschoof@gwdg.de.
  • von Bonin F; Department of Hematology and Oncology, Medical Center of the Georg-August-University of Göttingen, Göttingen.
  • Zeynalova S; Department of Statistics and Epidemiology, Institute of Medical Informatics, University of Leipzig, Leipzig.
  • Ziepert M; Department of Statistics and Epidemiology, Institute of Medical Informatics, University of Leipzig, Leipzig.
  • Jung W; Department of Hematology and Oncology, Medical Center of the Georg-August-University of Göttingen, Göttingen.
  • Loeffler M; Department of Statistics and Epidemiology, Institute of Medical Informatics, University of Leipzig, Leipzig.
  • Pfreundschuh M; Department of Internal Medicine I, Saarland University, Homburg/Saar, Germany for the DSHNHL (German High-Grade Non-Hodgkin's Lymphoma Study Group).
  • Trümper L; Department of Hematology and Oncology, Medical Center of the Georg-August-University of Göttingen, Göttingen.
  • Kube D; Department of Hematology and Oncology, Medical Center of the Georg-August-University of Göttingen, Göttingen.
Ann Oncol ; 20(9): 1548-1554, 2009 Sep.
Article en En | MEDLINE | ID: mdl-19515749
BACKGROUND: Recently published data indicate that host germline variations in immune genes can influence the outcome of lymphoma patients. Interleukin (IL)-4 and IL13 are crucial immune factors and may influence the course of the disease. Both cytokines signal through the interleukin-4 receptor (IL4R). Therefore, we investigated whether polymorphisms of IL4, IL13 and IL4R genes could predict the outcome of diffuse large B-cell lymphoma (DLBCL) patients. METHODS: In 228 DLBCL samples of the German High-Grade Non-Hodgkin's Lymphoma Study Group, the polymorphisms of IL4 (-524CT, rs2243250), IL13 (-1069CT, rs1800925) and IL4R (I75V, rs1805010; S503P, rs1805015; Q576R, rs1801275) were analyzed and the soluble interleukin-4 receptor (sIL4R) serum level was measured before the start of chemotherapy. RESULTS: Patients harboring IL4R V75 (IL4R(I75V-AG) and IL4R(I75V-GG)) had shorter overall survival (OS) (P = 0.044) and event-free survival (EFS) (P = 0.056) periods compared with I75 carriers (IL4R(I75V-AA)). Multivariate analysis adjusted to the International Prognostic Index revealed a relative risk of 1.9 for carriers of the IL4R V75 (P = 0.011) in relation to OS. DLBCL patients homozygous for the IL4R I75 and low sIL4R serum levels have the most favorable OS and EFS. CONCLUSIONS: These data support the role for host germline gene variations of immunologically important factors like the IL4R I75V gene variation to predict the survival in DLBCL patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfoma de Células B Grandes Difuso / Receptores de Interleucina-4 Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Oncol Asunto de la revista: NEOPLASIAS Año: 2009 Tipo del documento: Article Pais de publicación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfoma de Células B Grandes Difuso / Receptores de Interleucina-4 Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Oncol Asunto de la revista: NEOPLASIAS Año: 2009 Tipo del documento: Article Pais de publicación: Reino Unido