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Evidence of dysfunctional pain inhibition in Fibromyalgia reflected in rACC during provoked pain.
Jensen, Karin B; Kosek, Eva; Petzke, Frank; Carville, Serena; Fransson, Peter; Marcus, Hanke; Williams, Steven C R; Choy, Ernest; Giesecke, Thorsten; Mainguy, Yves; Gracely, Richard; Ingvar, Martin.
Afiliación
  • Jensen KB; Stockholm Brain Institute, Osher Center for Integrative Medicine, Karolinska Institutet, Stockholm, Sweden.
Pain ; 144(1-2): 95-100, 2009 Jul.
Article en En | MEDLINE | ID: mdl-19410366
Over the years, many have viewed Fibromyalgia syndrome (FMS) as a so-called "functional disorder" and patients have experienced a concomitant lack of interest and legitimacy from the medical profession. The symptoms have not been explained by peripheral mechanisms alone nor by specific central nervous system mechanisms. In this study, we objectively evaluated the cerebral response to individually calibrated pain provocations of a pain-free body region (thumbnail). The study comprised 16 female FMS patients and 16 individually age-matched controls. Brain activity was measured using functional magnetic resonance imaging (fMRI) during individually calibrated painful pressures representing 50 mm on a visual analogue scale (VAS) ranging from 0 to 100 mm. Patients exhibited higher sensitivity to pain provocation than controls as they required less pressure to evoke equal pain magnitudes (U(A)=48, p<.002). Despite lower pressures applied in patients at VAS 50 mm, the fMRI-analysis revealed no difference in activity in brain regions relating to attention and affect or regions with sensory projections from the stimulated body area. However, in the primary link in the descending pain regulating system (the rostral anterior cingulate cortex) the patients failed to respond to pain provocation. The attenuated response to pain in this brain region is the first demonstration of a specific brain region where the impairment of pain inhibition in FMS patients is expressed. These results validate previous reports of dysfunctional endogenous pain inhibition in FMS and advance the understanding of the central pathophysiologic mechanisms, providing a new direction for the development of successful treatments in FMS.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dolor / Estimulación Física / Fibromialgia / Giro del Cíngulo Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adult / Female / Humans / Middle aged Idioma: En Revista: Pain Año: 2009 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dolor / Estimulación Física / Fibromialgia / Giro del Cíngulo Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adult / Female / Humans / Middle aged Idioma: En Revista: Pain Año: 2009 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Estados Unidos