Hepatitis from Greater celandine (Chelidonium majus L.): review of literature and report of a new case.
J Ethnopharmacol
; 124(2): 328-32, 2009 Jul 15.
Article
en En
| MEDLINE
| ID: mdl-19397968
ETHNOPHARMACOLOGICAL RELEVANCE: Folk medicine is a rich source of useful therapeutic tools. Nevertheless, use of medicinal plants can have unwanted, negative effects. By means of the description of an adverse reaction to a herbal remedy, we highlight the need for better efficacy-toxicity studies on these products. AIM OF THE STUDY: To report a case of possible Chelidonium majus L. (Greater celandine)-induced hepatitis and evaluate the past published cases. MATERIALS AND METHODS: We outlined the main features of hepatitis associated with use of Chelidonium majus by providing a review of cases reported and analysing in detail a new one. RESULTS: Several cases of acute hepatitis related to Greater celandine consumption were found in the literature. The assessment for causality using Naranjo probability scale showed a probable relationship between the liver injury and the consumption of Chelidonium majus in the case we described. CONCLUSIONS: Our case, along with the other ones reported in the literature, increases the concern about the safety of oral use of Chelidonium majus. Plants used in traditional medicine are not necessarily harmless. Customers and prescribers should be aware of this, especially when a herbal drug is used with therapeutic purposes in absence of reliable studies of clinical efficacy and benefit-risk assessment.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Chelidonium
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Preparaciones de Plantas
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Enfermedad Hepática Inducida por Sustancias y Drogas
Tipo de estudio:
Risk_factors_studies
Límite:
Aged
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Humans
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Male
Idioma:
En
Revista:
J Ethnopharmacol
Año:
2009
Tipo del documento:
Article
País de afiliación:
Italia
Pais de publicación:
Irlanda